Monday, 9 July 2018

How autophagy could lead to a cure for cancer and spell the end for diabetes?


How autophagy could lead to a cure for cancer and spell the end for diabetes? 

Nobel Prize winner Yoshinori Ohsumi is pictured in his laboratory

Also known as 'self-eating', autophagy is the process in which cells degrade and recycle their components.

Dr Ohsumi's research studied the genetic makeup of yeast to discover the genes involved in this cellular activity and his work has already led to a better understanding of diseases such as cancer, Parkinson's and type 2 diabetes.

Autophagy (illustrated) provides fuel for energy and building blocks for renewal of cells. After infection, autophagy can destroy bacteria and viruses and it contributes to embryo development as well cell differentiation
What did Dr Ohsumi discover?
As part of Dr Ohsumi's initial research, he used yeast to identify the genes that are responsible for autophagy and how this technique is similar in our own cells.

In 1988, he particularly studied how proteins degraded in a region called the vacuole, an organelle that corresponds to the lysosome in human cells. Ohsumi proposed that if he could disrupt the degradation process in the vacuole, while autophagy was taking place, autophagosomes should build up within the vacuole and become visible under the microscope.

Read the complete article at
Contact: Dr Pramod Tripathi office 7776077760

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